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Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals
Ohsawa I, Ishikawa M, Takahashi K, et al. · Nature Medicine · 2007· DOI
The foundational paper establishing molecular hydrogen as a selective antioxidant. Demonstrates H2's ability to neutralize hydroxyl and peroxynitrite radicals without affecting beneficial reactive species.
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Beneficial biological effects and the underlying mechanisms of molecular hydrogen
Ichihara M, Sobue S, Ito M, Ito M, Hirayama M, Ohno K · Medical Gas Research · 2015· DOI
Comprehensive review of 321 publications on molecular hydrogen therapy across 166 disease models. The most cited single review in the H2 literature.
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Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes
Aoki K, Nakao A, Adachi T, Matsui Y, Miyakawa S · Medical Gas Research · 2012· DOI
Randomized controlled trial in elite male soccer players showing H2-rich water consumption pre-exercise reduced blood lactate accumulation and prevented decline in exercise-induced muscle function.
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Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors
Kang KM, Kang YN, Choi IB, et al. · Medical Gas Research · 2011· DOI
Randomized placebo-controlled study of 49 patients showing H2-rich water consumption significantly improved QoL scores and reduced biomarkers of oxidative stress during radiation therapy.
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A randomized, double-blind, placebo-controlled trial of hydrogen-rich water on metabolic syndrome
LeBaron TW, Singh RB, Fatima G, et al. · Medical Gas Research · 2020· DOI
24-week RCT in 60 subjects with metabolic syndrome showing H2-rich water reduced cholesterol, glucose, and inflammatory markers vs placebo.
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Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators
Iuchi K, Imoto A, Kamimura N, et al. · Scientific Reports · 2016· DOI
Identifies the upstream molecular mechanism by which H2 selectively modulates gene expression — through reduction of free-radical-derived oxidized phospholipid mediators.
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Recent advances in studies of molecular hydrogen against sepsis
Liu X, Ma C, Wang X, et al. · International Journal of Biological Sciences · 2024· DOI
Recent meta-analysis of H2 therapy applications across sepsis treatment models. Synthesizes a decade of post-Ohsawa research.
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Hydrogen as a selective antioxidant: a review of clinical and experimental studies
Huang CS, Kawamura T, Toyoda Y, Nakao A · Journal of International Medical Research · 2010· DOI
Review of H2's selectivity — the property that distinguishes it from broad-spectrum antioxidants like vitamin C. Critical for understanding why H2 doesn't blunt exercise adaptation.